Joseph Murray, MD

I am a Professor of Medicine and a Consultant with a joint appointment in Immunology and Gastroenterology and Hepatology. My training in gastroenterology, population health, as well as my experience in mucosal immunology, makes me well suited for the project described here. My training as a gastroenterologist, particularly in small bowel diseases and my engagement in mucosal immunology is highly pertinent to the studies proposed and complementary to the Yale Team’s extensive expertise. I have particular experience studying the mucosal responses to luminal antigens, particularly food-derived antigens, but more recently, microbial antigens. I have been engaged in studies involving mucosal integrity, both in human disease and in these mouse models. I can bring this experience, derived from both bedside and bench, to bear on the design of studies and assist my colleagues in the experimental design, analysis, and interpretation of results. I have additional expertise in investigating the role of human commensals and probiotics in altering the immune responses to food antigens. I run a busy clinical practice and clinical trials devoted to celiac disease providing access to biospecimens suitable for this research. I have published over 400 original articles primarily in the topics of celiac disease, malabsorption, esophageal disease, and esophageal physiology. My research has spread the gambit from basic work to clinical trials all the way through translational work through clinical trials. I have also participated in guideline development and have been the senior author on guidelines related to celiac disease. I have also been an active participate in the Clinical Practice Update Committee as well as co-authoring two of the clinical updates both of which were published in Gastroenterology.